Sensibio Defensive

• Long-lastingly moisturizes the skin (hydration level +71%**) ⁽¹⁾
• Reinforces the skin against internal and external aggression (-29%*** TEWL(a)⁽²⁾, antioxidant properties ⁽³⁾)
• Immediately and long-lastingly soothes the skin (-16%** of cutaneous microcirculation after mechanical stress (4), -43%*** of intensity of stinging sensation (5), -50%*** of global unpleasant symptoms of skin sensitivity ⁽⁶⁾)
• Improves quality of life (-46%*** in apprehension to cope with urban pollution because of sensitive skin ⁽⁷⁾, -14.1%* BoSS score ^(b)(8))

Very high cutaneous tolerance – Fresh and light texture – Penetrates quickly.

Clinically tested on patients with dry sensitive skin.

(a)TEWL: Trans Epidermal Water Loss. The lower it is, the more water remains in the skin and therefore the barrier function of the skin is important.
(b)BoSS (Burden of Sensitive Skin) questionnaire is a reliable tool developed to self-assess skin sensitivity and may be an efficient method for screening patients and evaluation of specific cares efficacy. It is made up of 14 questions (Misery et al. 2018 – PMID: 30022546)

*P<0.05, Wilcoxon Test, after 28 days / **P<0.01 Student ‘test, after 30 min or 12 hours / ***P<0.001 student’ Test; after 30 seconds or 28 days

(1)Evaluation of hydration level of Sensibio Defensive - 11 volunteers (aged 32 - 60 years old) with dry skin with only one application. Poland.2020

(2)Evaluation of protective effect by measurement of TEWL of Sensibio Defensive - 22 patients (aged from 19 - 70 years old) with dry skin with twice daily use of Sensibio Defensive. Poland. 2020

(3)Evaluation of antioxidant properties of Sensibio Defensive by in tubo ORAC test. France.2021

(4)Evaluation of soothing efficacy of Sensibio Defensive after mechanical erythema induced by stripping by cutaneous microcirculation measurement using TiVi700 - 18 patients (aged 21 - 55 years old) with sensitive skin with only one application. Poland. 2020.

(5)Evaluation of soothing efficacy of Sensibio Defensive by capsaicin test - 22 patients (aged 18 - 60 years old) with sensitive and reactive skin with twice daily use. Poland. 2020.

(6)Evaluation of efficacy and tolerance of Sensibio Defensive on 29 patients (aged 24 - 51 years old) with sensitive skin in presence or not of hot-cold stress by clinical scorage.

(7)User test on Sensibio Defensive – 33 volunteers (aged 25 – 59 years old) with sensitive skin on the face with twice application. China. 2020.

(8)User test on Sensibio Defensive – 50 volunteers (aged 18 – 60 years old) with normal to combination, sensitive and reactive skin. Portugal.2020.

> CLINICAL RESULTS

Sensibio Defensive significantly moisturizes the skin as quickly as 30 minutes after application (level of hydration + 110%**) and long-lastingly - 12h after application (level of hydration +71%**) (1)

Sensibio Defensive also limits oxidative stress ⁽²⁾ and induces a significant decrease in Transepidermal Water Loss (TEWL) ^(a) by -29%*** ⁽³⁾ after 28 days of application, which results in reinforcement of skin barrier function protecting it against environmental stress.

ACTION ON SENSITIVE SKIN

• Immediately after use, it decreases the cutaneous temperature by -1.5°C in 3 minutes after application ⁽⁴⁾, significantly decreases the cutaneous microcirculation by 16%** after mechanical stress ⁽⁵⁾ and significantly decreases the intensity of stinging sensation by 43%*** after capsaicin application (6) which demonstratess an immediate refreshing and soothing efficacy.
• After 28 days of use, it significantly improves the cutaneous reactivity to capsaicin by +78%*** ⁽⁶⁾, redness scorage by -42%*** ⁽⁷⁾ and decreases global unpleasant symptoms of skin sensitivity by -50%*** ⁽⁸⁾ demonstrating a long-lasting soothing benefit.

After a thermal hot-cold stress and 28 days of application of Sensibio Defensive, the following effects were observed ⁽⁸⁾:

• A remarkable decrease of 21%* in global unpleasant symptoms of skin sensitivity suggesting it long-lastingly soothes the skin in presence of heat-cold aggressions
• A significant increase in hydration level of +24%***
• A notable protective effect of heat-cold aggressions with no significant variation of TEWL ^(a) in comparison with control condition, barrier function reacts better to stress with Sensibio Defensive.
• A considerable decrease in release of pro-inflammatory biomarkers at the epidermal level by heat-cold stress

ACTION ON QUALITY OF LIFE
After 28 days of use, Sensibio Defensive significantly improves quality of life by inducing a pronounced:

• Decrease in subjects’ apprehension to cope with urban pollution because of their sensitive skin of 46%*** ⁽⁷⁾
• Decrease in the average of BoSS score ^(b) of 14.1%* demonstrated a positive impact on skin sensitivity ⁽¹⁰⁾

(a)TEWL: Trans Epidermal Water Loss. The lower it is, the more water remains in the skin and therefore the barrier function of the skin is important.
(b)BoSS (Burden of Sensitive Skin) questionnaire is a reliable tool developed to self-assess skin sensitivity and may be an efficient method for screening patients and evaluation of specific cares efficacy. It is made up of 14 questions (Misery et al. 2018 – PMID: 30022546)

*P<0.05, Wilcoxon Test, after 28 days / **P<0.01 Student ‘test, after 30 min or 12 hours / ***P<0.001 student’ Test; after 30 seconds or 28 days

TOLERANCE
Very good cutaneous tolerance in sensitive or reactive skins in presence of heat-cold stress or with redness related to pollution  ^(7,8,10,11)

> PATIENTS FEEDBACKS
Immediately after use, for more than 97% of subjects, skin feels comfortable and protected ⁽¹¹⁾

After 28 days of use, for more than 94% of subjects, skin is:

• less sensible, sensitized and reactive ⁽¹¹⁾
• more resistant ⁽¹¹⁾
• soothed ⁽¹¹⁾
• skin feels protected against external aggressions ⁽⁸⁾

Subjects feel also more self-confident, their quality of life is improved, and their skin’s sensitivity has less impact on daily life for 94% of subjects ⁽¹¹⁾

For more than 91% of subjects, the product penetrates quickly, is not noodling on the skin, can be used as a make-up base and its texture is light and pleasant ⁽¹¹⁾.

(1)Evaluation of hydration level of Sensibio Defensive - 11 volunteers (aged 32 - 60 years old) with dry skin with only one application. Poland.2020
(2)Evaluation of antioxidant properties of Sensibio Defensive by in tubo ORAC test. France.2021
(3)Evaluation of protective effect by measurement of TEWL of Sensibio Defensive - 22 patients (aged from 19 - 70 years old) with dry skin with twice daily use of Sensibio Defensive. Poland. 2020
(4)Evaluation of refreshing effect by measurement of cutaneous temperature by thermography on 14 patients (aged 20 - 68 years old) with normal to dry skin immediately after use (from few seconds to 3 minutes)
(5)Evaluation of soothing efficacy of Sensibio Defensive after mechanical erythema induced by stripping by cutaneous microcirculation measurement using TiVi700 - 18 patients (aged 21 - 55 years old) with sensitive skin with only one application. Poland. 2020.
(6)Evaluation of soothing efficacy of Sensibio Defensive by capsaicin test - 22 patients (aged 18 - 60 years old) with sensitive and reactive skin with twice daily use. Poland. 2020.
(7)Evaluation of efficacy and tolerance of Sensibio Defensive - 33 patients (aged 26 - 50 years old) with sensitive skin and facial redness related to pollution.
(8)Evaluation of efficacy and tolerance of Sensibio Defensive - 29 patients (aged 24 - 51 years old) with sensitive skin in presence or not of hot-cold stress, triggering factor of sensitivity by clinical scorage, instrumental measurement, ELISA dosage of biomarkers, and self-assessment.
(9)User test on Sensibio Defensive – 33 volunteers (aged 25 – 59 years old) with sensitive skin on the face with twice application. China.2020
(10)User test on Sensibio Defensive – 50 volunteers (aged 18 – 60 years old) with normal to combination, sensitive and reactive skin. Portugal.2020
(11)Evaluation of tolerance and comedogenic potential by clinical examination and self-assessment of efficacy (% of satisfaction) - 31 patients (aged 23 - 49 years old) with combination to greasy skin after 28 days of use.