Sensibio Defensive rich

• Long-lastingly moisturizes the skin (+43%** hydration after 8 hours vs D0) ⁽¹⁾
• Reinforces the skin against internal and external aggression and nourishes the skin (antioxidant properties ⁽²⁾, -21%** in TEWL) ^(a)(3)
• Immediately and long-lastingly soothes the skin (-20%** of cutaneous microcirculation after mechanical stress ⁽⁴⁾, -44%** of intensity of stinging sensation ⁽⁵⁾)
• Improves quality of life (-15.1%* BoSS score(b)(6), improvement in self-confidence and quality of life for more than 88% of subjects ⁽⁷⁾)

Very high cutaneous tolerance – Non-comedogenic – Rich, enveloping and pleasant texture – Non-perfumed – Penetrates quickly

(a)TEWL: Trans Epidermal Water Loss. It reflects water loss. The lower it is, the better the skin's barrier function.
(b) BoSS (Burden of Sensitive Skin) questionnaire is a reliable tool developed to self-assess skin sensitivity and may be an efficient method for screening patients and evaluation of specific cares efficacy. It is made up of 14 questions (Misery et al. 2018 – PMID: 30022546)
*p<0.05, Student t-test vs D0 ** p<0.001, Student t-test vs D0
(a) TEWL: Trans Epidermal Water Loss. The lower it is, the more water remains in the skin and therefore the barrier function of the skin is important

(1)Evaluation of hydration level on 10 volunteers aged from 21 to 60 years old with dry skin by corneometry 30mn, 8h and 12h after use of Sensibio Defensive RICH ** p<0.001 paired student t.test vs D0
(2)Evaluation of antioxidant properties of Sensibio Defensive RICH by in tubo ORAC test
(3)Evaluation of protective effect by measurement of TEWL on 22 subjects aged from 24 to 69 years old with dry skin after 28 days of using Sensibio Defensive RICH. Poland. 2020
(4)Evaluation of soothing efficacy after mechanical erythema induced by stripping by cutaneous microcirculation measurement using TiVi700 on 20 subjects aged from 19 to 59 years old with sensitive skin 30 minutes after use of Sensibio Defensive RICH. Poland. 2020
(5)Evaluation of soothing efficacy by capsaicin test on 22 subjects aged from 21 to 54 years old with sensitive and reactive skin on the face 30 seconds after use and 28 days after twice daily use of Sensibio Defensive RICH. Poland. 2020
(6)Evaluation of tolerance by clinical examination and self-assessment of efficacy on 51 subjects aged from 18 to 60 years old with sensitive and reactive skin after 28 days of twice daily use of Sensibio Defensive RICH. Portugal. 2020
(7)Evaluation of tolerance by clinical examination and self-assessment of efficacy on 32 subjects aged from 32 to 60 years old with sensitive and reactive skin after 28 days of twice daily use of Sensibio Defensive RICH. China. 2020

> CLINICAL RESULTS

FIGHTS AGAINST REDNESS & STINGING SENSATION
DEFENSIVE TECHNOLOGY acts on the causes of sensitive skin and prevents sensitivity induced by environment and lifestyle.

Sensibio Defensive Rich limits oxidative stress thanks to Defensive technology⁽²⁾. In vitro test, realized on reconstructed epidermis exposed to UVA rays and pollution, showed that Defensive technology offers +75% of antioxidant protection compared to the non-treated stressed reconstructed epidermis.

DEFENSIVE TECHNOLOGY integrates Red Sage polyphenols (Salvia miltiorrhiza extract) which limits the hyper-reactivity of the skin and limits the cutaneous inflammation induced by aggressions.

Sensibio Defensive RICH:

• significantly decreases the cutaneous microcirculation of 20%** after mechanical erythema induced by stripping vs untreated area⁽⁵⁾
• Immediately after use, it decreases the cutaneous temperature by -1.4°C within 3 minutes after application⁽⁴⁾,
• significantly decreases the intensity of stinging sensation of 44%** after capsaicin application⁽⁶⁾ which characterizes an immediate refreshing and soothing efficacy.

After 28 days of use, twice daily, it significantly improves the cutaneous reactivity to capsaicin of 58%***.⁽⁶⁾ Their skin is more comfortable and soothed⁽⁷⁾

FIGHTS AGAINST DRYNESS
Sensibio Defensive significantly moisturizes the skin as soon as in 30 minutes (level of hydration +157%**) and lastingly (level of hydration +43%** after 12 hours)⁽¹⁾

It induces a significant decreased in Transepidermal Water Loss (TEWL) of -21%**⁽³⁾ after 28 days of application which results in reinforcement of skin barrier function and its protection against environmental stress.

QUALITY OF LIFE & TOLERANCE
After 28 days of use, Sensibio Defensive significantly improves quality of life by inducing a significant decrease in the average of BoSS score^(a) of 15.1%* and demonstrates a positive impact on skin sensitivity⁽⁸⁾

Demonstrates very high cutaneous tolerance on sensitive and reactive skin^(7,8,9)

(a) BoSS (Burden of Sensitive Skin) questionnaire is a reliable tool developed to self-assess skin sensitivity and may be an efficient method for screening patients and evaluation of specific cares efficacy. It is made up of 14 questions (Misery et al. 2018 – PMID: 30022546)
*p<0.05 student t-test ** p<0.001, Student t-test

> PATIENTS FEEDBACKS
After 28 days of use twice a day, more that 90% of patients with sensitive & reactive dry to very dry face skin thought that:

• their skin feels immediately protected, comfortable, soothed & moisturized⁽⁷⁾
• their skin is nourished, soothed, less sensitive and reactive⁽⁷⁾  but also more resistant and protected against aggressions⁽⁷⁾ 

For more than 88% of subject, Sensibio Defensive Rich improves self-confidence, quality of life, skin’s sensitivity has less impact on daily life and is under control⁽⁷⁾.
For more than 91% of subject, texture is rich, enveloping, and pleasant and the product penetrates quickly⁽⁷⁾.

(1)Evaluation of hydration level in 10 volunteers (aged 21 to 60 years old) with dry skin on forearms by corneometry 30mn, 8h and 12h after use of Sensibio Defensive RICH. Poland.2020
(2)Evaluation of antioxidant properties of Sensibio Defensive RICH by in tubo ORAC test. France. 2021
(3)Evaluation of protective effect by measurement of TEWL on 22 subjects aged from 24 to 69 years old with dry skin after 28 days of using Sensibio Defensive RICH. Poland. 2020
(4)Evaluation of refreshing effect by measurement of cutaneous temperature by thermography on 14 subjects aged from 20 to 68 years old with normal to dry skin immediately after use (from few seconds to 3 minutes) of Sensibio Defensive RICH. France. 2020
(5)Evaluation of soothing efficacy after mechanical erythema induced by stripping by cutaneous microcirculation measurement using TiVi700 on 20 subjects aged from 19 to 59 years old with sensitive skin 30 minutes after use of Sensibio Defensive RICH. Poland. 2020
(6)Evaluation of soothing efficacy by capsaicin test on 22 subjects aged from 21 to 54 years old with sensitive and reactive skin on the face 30 seconds after use and 28 days after twice daily use of Sensibio Defensive RICH. Poland. 2020
(7)Evaluation of tolerance by clinical examination and self-assessment of efficacy on 32 subjects aged from 32 to 60 years old with sensitive and reactive skin after 28 days of twice daily use of Sensibio Defensive RICH. China. 2020
(8)Evaluation of tolerance by clinical examination and self-assessment of efficacy on 51 subjects aged from 18 to 60 years old with sensitive and reactive skin after 28 days of twice daily use of Sensibio Defensive RICH. Portugal. 2020
(9)Evaluation of cutaneous acceptability and comedogenic potential on 33 subjects aged from 18 to 38 years old with combination to greasy skin by clinical examination after 28 days of daily use of Sensibio Defensive RICH. Italy. 2020