Evidence of defective fattyacidome and aminoacidome in sebaceous and non sebaceous skin areas in atopic dermatitis

Authors: Alessia Cavallo, Maria Mariano, Grazia Bottillo, Miriam Maiellaro, Flavia Pigliacelli, Marlène Chavagnac, Aurélie Fauger, Mauro Truglio, Antonio Cristaudo, Emanuela Camera

Original poster from ESDR (2021)

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The overall results demonstrated deranged sebogenesis in adult AD. Declined sebometry and disruption of the SBP were associated with decreased levels of lipids of both sebaceous type (squalene, MUFAs, BCFAs) and epidermal types (SCFAs, C24:0). In particular, squalene was significantly depleted in both SGR and SGP areas. Bio-signature of sebum in the SC in association with aminoacidome and skin physical properties may serve the better definition of AD phenotypes.

Poster_Collaboration Picardo_ESDR 2021 DOCUMENT

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Space (for) oddity at the skin surface: Enlarged view on the ceramide bio-signature in sebaceous and non sebaceous areas in atopic dermatitis

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Evidence of defective fattyacidome and aminoacidome in sebaceous and non sebaceous skin areas in atopic dermatitis

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