Space (for) oddity at the skin surface: Enlarged view on the ceramide bio-signature in sebaceous and non sebaceous areas in atopic dermatitis

Medium-to-short and odd chained ceramide species (C≤42) participated into the discrimination between sebaceous and non-sebaceous areas inhealthy conditions. Facial (SGR) sphingolipid signature was more effective than arm (SGP) sphingolipidome in discriminating controls from both AD groups. Modification of AH, AP, and NS ceramides levels was more pronounced at SGR areas than arm. Odd-chained ceramides accounted for half of the total discriminating species in all cases. These findings support a role played by the SG in the plasticity of the SPB in both physiologic and pathologic conditions. Ceramide bio-signature in sebaceous areas may empower the characterization of AD patients.